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Arthritis Rheum (1999) 42(1):909.10.1002/1529-0131(199901)42:1 3.0.CO;2-A 56 van HoltenJReedquistKSattonet-RochePSmeetsTJPlater-ZyberkCVervoordeldonkMJet alTreatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis

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The clinical phenotype of the acute phase would prove to be of paramount importance in the assessment of the patients immune status only three decades later