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The activation of Nrf2 has been shown to reduce bisphenol A-induced lipid accumulation in the liver of mice, and its efficacy in inhibiting lipid accumulation is considered to be related to the enhanced expression of genes coding for antioxidants and detoxification enzymes (Ludtmann et al., 2014

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2025b) or PCLiS might aid in confirmation of screening results or serve as reference model in establishment of advanced liver cell models for genotoxicity testing of NAs

NAC directly replenishes intracellular glutathione, restoring feedback inhibition on the gamma-glutamyl cycle and reducing 5-oxoproline accumulation [6]