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Nho KJ, Chun JM, Kim HK

His-38 and His-50 are located within polar interaction distance of the glycyl carboxylate moiety of GSH [80, 84, 85]

Rhamnetin has been shown to activate Nrf2, facilitating its movement into the nucleus and enhancing the expression of these antioxidant enzymes, including Mn-SOD and catalase

The formation of a hydrogen bond between residue 72 and the sulfur atom in GSH resulted in the orientation of the sulfur atom toward the redox active site of the Grx domain (2.6 distance from C28 sulfur) (Fig 3B), which was responsible for the delivery of reducing equivalents