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Similarly, exposure to childhood maltreatment was associated with hypermethylation of NR3C1 regulatory sites, particularly within the early growth response 1 (EGR1) binding region ( Based on a longitudinal study, the authors broaden this perspective by showing that methylation of HPA axis genes, including NR3C1, CRH, corticotropin-releasing hormone receptor 1 (CRHR1), and corticotropin-releasing hormone receptor 2 (CRHR2), predicts the risk of MDD during adolescence and early adulthood (Humphreys et al., 2019)

Impaired mitochondrial calcium uniporter (MCU) activity decreases mitochondrial Ca 2+ uptake and thereby impairs activity of Ca 2+ -dependent dehydrogenases and oxidative phosphorylation

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