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Considering the global burden of cardiovascular disease, the growing evidence linking MNP exposure to cardiac dysfunction calls for proactive scientific and regulatory responses

10.1016/j.jtcme.2016.05.005 9 AshrafizadehM.AhmadiZ.MohammadinejadR.FarkhondehT.SamarghandianS

These novel findings are complemented by the demonstration of reduced GPx1 in the colon of mice with DSS-induced colitis [41, 42], murine colitis induced by knockout of GPx1 and GPx2 [43], and genome-wide association studies that note polymorphisms in antioxidant genes, including GPxs in IBD [44, 45]