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In the STEP 1 trial, semaglutide led to an average 14.9% reduction in body weight over 68 weeks , far outperforming placebo (NEJM study on semaglutide for weight loss)

A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

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These effects are context-dependent and vary with concentration, exposure duration, and experimental system, making GHK-Cu a widely used molecular tool for investigating copper-mediated signalling and peptidemetal interactions in vitro and in vivo