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This epigenetic influence adds a new dimension to their anticancer activity

Furthermore, a randomized controlled trial in patients with chronic hepatitis C demonstrated that combination therapy with UDCA and glycyrrhizin produced significantly greater reductions in serum aminotransferases and -glutamyl transpeptidase (-GTP) compared to glycyrrhizin alone, without affecting HCV RNA levels, indicating a hepatoprotective rather than antiviral synergy (Tsubota et al., 1999)

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A number of previous studies that have specifically investigated the types of neurodevelopmental regression that have been seen in ASD have shown that these developmental changes may be associated with mitochondrial dysfunction, associated with impairment of oxidative phosphorylation and in some cases, this may lead to a disruption of the electron transport chain in the brain (155)

10.1038/s41597-019-0256-6 Summary Keywords cystic fibrosis, oxidative stress, inflammation, analytic techniques, ROS Citation Rubin M, Artusi I and Cozza G (2025) Mapping the oxidative landscape in cystic fibrosis: methodological frontiers and application