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Koch S, Kucharzik T, Heidemann J, Nusrat A, Luegering A

PMID 9437700

demonstrated that histone deubiquitinase MYSM1 (Myb-like, SWIRM and MPN domains 1) deficiency reduced the translation of ferroptosis-protective mRNAs, resulting in increased ferroptosis of human hematopoietic stem cells (HSCs), and HSC population maintenance was fully restored by the ferroptosis inhibitors ( e.g., deferoxamine (DFO), ferrostatin-1 (Fer-1), and vitamin E)[16]