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The U87vIII CHCHD2 WT and KO cells were transfected with genetically encoded, fluorescent redox biosensors targeted to the cytosol (cyto-Grx1-roGFP2) or mitochondrial matrix (mito-Grx1-roGFP2), previously described by the authors' laboratory (30)

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women: 45%) versus 130 AD patients (mean age: 73

ALS genetics: Gains, losses, and implications for future therapies

Upon repletion of nutrient-rich culture medium, p53 protein and target gene expression levels were returned to basal levels after 3 h (Supplementary Fig