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Conversely, in acidic niches such as the tumor microenvironment (TME) or bacterial infection sites, POD-like activity is markedly enhanced, steering H 2 O 2 toward OH generation and pro-oxidant effects

Serasanambati M, Chilakapati SR

It consists of the enzymatic transfer of a methyl group (-CH 3 ) to the carbon-5 position of the cytosine base within the cytosine-guanine (CpG) dinucleotide, leading to the formation of 5-methylcytosine (5mC) [12]

In addition, the database lacks detailed clinical data, including treatment regimens, concomitant therapies, treatment duration, and imaging findings, which limits accurate incidence estimation and precludes causal inference

Georgiades, F., Hosgood, S