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Indications: Guanethidine is no longer available in the USA due to lack of availability, but is available in the UK (wikipedia) Was used for severe cases of hypertension, either alone or as an adjunct drug Contraindications: Guanethidine can cause a hypertensive crisis in patients with pheochromocytoma due to the release of catecholamines (tyramine like action)

Glutathione solution will be administered

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Aliquots taken from methanol solution at each of the time points were concentrated in vacuo, mixed with water, and extracted with ethyl acetate