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Cooperation of condensin and mediator to form mitotic chromosome architecture By comparing Hi-C data from Cnd1-Pmc4 double depletion with that from Cnd1 or Pmc4 single depletion, we find that condensin primarily contributes to genomic contacts within approximately 800 kb, whereas mediator appears to exert an inhibitory effect on genomic contacts within roughly 800 kb (Supplementary Fig