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By reducing melanin production, glutathione helps lighten existing pigmentation and prevents new melanin formation, resulting in a gradual lightening of the skin tone over time

3.4 Iron While iron deficiency (ID) has long been recognized as a driver of ineffective erythropoiesis in CKD, emerging evidence highlights that both iron deficiency and iron overload disrupt RBC longevity by promoting eryptosisthe programmed, non-hemolytic death of mature erythrocytes characterized by PS externalization, cell shrinkage, and cytoskeletal rearrangement (Lang K

Contribution statement MJ and D-KC: Conceived and designed the study

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2) chondrectomy (Ch.tomy): articular cartilage was damaged but received no treatment