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If you have no bowel action for 3 days or more, ask your GP to prescribe you a laxative (Sugar Free Liquid Sodium Docusate), but avoid Fybogel or Movicol

Best utilized for OA but can also aid in RA as well

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Next to the localization to the ER, SnCE1 shows strong co-localization with a mitochondrial marker (mito-GFP), suggesting an enrichment of SnCE1 at mitochondria or at ER-mitochondria contact sites