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Consequently, the development of agents with high CNS bioavailability, selective target engagement, and minimal adverse effects, confirmed by well-powered, stage-stratified clinical trials, will therefore be necessary to determine their clinical utility, even though inducers and NLRP3 inhibitors continue to be promising candidates for disease-modifying therapy

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Mlynrik V, Gambarota G, Frenkel H, Gruetter R (2006) Localized short-echo-time proton MR spectroscopy with full signal-intensity acquisition