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The 5 subunit regulates the expression and function of 4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area

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To improve early detection and increase the signal-to-noise ratio for adjunctive trials of antioxidants, anti-inflammatory and NMDAR modulator drugs, the above presented processes allow to identify mechanism-based biomarkers guiding stratification of homogenous patients groups and target engagement required for successful clinical trials, paving the way towards precision medicine in psychiatry [90, 116, 143, 209, 212]