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Description

NMR solution structure of a DNA dodecamer duplex containing a cis -diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin

The dose-response curve is biphasic: low doses act as an electron carrier and antioxidant, while high doses can become pro-oxidant and act as a strong MAOI

BH3-only proteins respond to apoptotic stimuli by activating effectors, typically BAX and BAK

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