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4 Conclusion In general, the auto-reactive cellular immune responses including osteoclasts, synovial fibroblasts, T cells, B cells, NK cells, macrophages and DCs, play major roles in RA pathogenesis, although soluble inflammatory and rheumatoid factors with inflammatory natures were also involved

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Inhibition of cytochrome P450 enzymes by rhein in rat liver microsomes

DNA methylation is an epigenetic modification that controls gene expression, typically occurring at the fifth position of the cytosine base in mammals to generate 5-methyl-cytosine (5mC)

Mice were i.p