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Preclinical signals regarding potential effects on thyroid C-cells (observed with GLP-1 agonists as a class), as well as theoretical questions about bone metabolism and cardiovascular function, are being monitored in ongoing trials

Of note, phosphorylation levels of ERK1/2 (p-ERK1/2) and PKC (p-PKC) were equal between WT and XKR8 KO BMNs, indicating that these upstream signaling pathways remain intact in the absence of XKR8 (Extended Data Fig

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Furthermore, -hydroxybutyrylation was identified on histones, offering a new type of chromatin regulation as well 79

This suggests that the quinone head group is a structural requirement for the anti-ferroptotic function