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This relationship is theorized as a key susceptibility factor within PD-relevant A9 neurons in SN region that contain dopamine susceptible to ROS-induced adduct formation by DJ-1, further supported by in vivo evidence of elevated -synuclein aggregates in DJ-1 deficient mice leading to the increased oxidized form of DA 10,156

In agreement, the protein amounts augmented rapidly after PH before decreasing in a time-dependent manner until 48 h (Figure 1b)

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doi: 10.1111/j.1532-5415.1988.tb04397.x 27 InfanteMLeoniMCaprioMFabbriA

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