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Additionally, the polyol pathway has been implicated in hyperglycemia-induced, PKC-directed NF-B activation, as inhibition of aldose reductase is able to mitigate both PKC and NF-B activation in cultured rat aortic smooth muscle cells [23]

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ART was catalyzed by endogenous Fe 2+ to generate O 2 , which combined with PP to catalytically produce OH, thereby achieving a synergistic anti-tumor effect

In these three studies, SARS-CoV-2 viral infection in NCI-H1299 cells, Vero FM cells 41 , and HeLa cells expressing human ACE2 55,56 inhibited autophagic activity by blocking autophagosomelysosome fusion