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In bladder cancer cells, the combination of triptolide and hydroxycamptothecin significantly enhances G0/G1 phase arrest by inhibiting CDK4, CDK6, and Cyclin D1

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Therefore, deficiency of a critical autophagy gene, e.g., Atg5 , was expected to cause more severe injury after APAP overdose

10.1038/s41586-022-05660-7 146 PetrusP.LecoutreS.DolletL.WielC.SulenA.GaoH.et al (2020)