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Foxp3 expressing CD4+CD25(high) regulatory T cells are overrepresented in human metastatic melanoma lymph nodes and inhibit the function of infiltrating T cells

doi: 10.3389/fcell.2021.711003 11

In glioblastoma, PHGDH binds to and stabilizes the transcription factor FOXM1, sustaining the expression of downstream targets (e.g., VEGF, CCND1, CHK2, and MMP-2 ) to drive glioma cell proliferation, invasion, and tumorigenicity [113] (Fig