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The peptide structure is vulnerable to oxidation and aggregation, making strict adherence to storage temperature (28C) and protection from light non-negotiable

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54 However, previous studies have also demonstrated that MSCs are capable of secreting anti-inflammatory cytokines, anticatabolic mediators, and growth factors when cultured under IDD-like conditions both in vitro 55 and ex vivo, 56 hence demonstrating an immunomodulatory effect on resident IVD cells