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[DOI] [PubMed] [Google Scholar] 74.Garca-Lafuente A., Guillamn E., Villares A., Rostagno M.A., Martnez J.A

( 2 O 2 , a potent ROS-inducer, and superoxide dismutase (SOD), a natural antioxidant agent, were higher in GO then control OFs, whereas the ROS antagonist glutathione peroxidase (GPX) was reduced, with a reduced ratio between glutathione and oxidized glutathione, suggesting the presence of a remarkable state of oxidative stress ( Glycosaminoglycan Production and Heat Shock Protein 72 Expression in Orbital fibroblasts As mentioned above, the release of GAGs plays an important role in the pathogenesis of GO

NAD+ is essential to mitochondrial energy production

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