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10.1152/ajprenal.00422.2018 121 WeiW.YangL.WangB.TangL.LiJ.LiuC.et al (2025)

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PMCID: PMC12112738

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However, a single enzyme, common to Schistosoma spp ., was identified to possess both GR and TrxR activities ( SCHEME 1 TGR from Schistosoma mansoni (SmTGR) is a homodimeric, flavin-dependent enzyme which can accept electrons from nicotinamide adenine dinucleotide phosphate (NADPH) and reduce both oxidized glutathione (GSSG) and thioredoxin (Trx ox ) (Scheme 1)

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LinkermannASkoutaRHimmerkusNMulaySRDewitzCDe ZenFet al

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Hence, this work provides novel mechanistic insight into the metabolic changes associated with aspirin-mediated apoptosis

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