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The LLPS state is maintained until the particle reaches a large dilution ratio ( d m / d m,dry approaching 9), corresponding to a high a w value of 0.9999 (Supplementary Table 1)

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Once, the K-value is calculated, then the calculator calculates the pressure drop with the below equation

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277 The phosphorylcholine polymer exhibited long-lasting circulation and achieved higher accumulation in brain tumor tissue, serving as an effective tool for BBB crossing