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Studies have shown that the pH of chronic infection wounds increases to 6.58.5, with the alkaline environment likely resulting from necrotic tissue, bacteria, and bacterial byproducts such as ammonia, which create favorable conditions for bacterial growth

In PD, mitochondrial toxins like MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and rotenone induce oxidative stress and calcium overload, while -synuclein (-syn) accumulates at mitochondria and induces mPTP opening [52]

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Specifically, calorie restriction or intermittent fasting is currently the most effective dietary intervention to prolong a healthy lifespan 6 and prevent cancer development 7