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This paradoxical hypodipsic hyperosmolality results in aquaresis, extracellular volume depletion, and secondary activation of compensatory systems such as the sympathetic nervous system and RAAS

The inflammation-fibrosis-cancer cascade is not an inevitable pathway, but it does create a favorable environment for tumor development (Feng et al., 2025)

Targeting lipin-1 therapeutically will therefore require careful attention to disease context, timing, and selectivity

They are strongly oxidizing and, at high concentrations, are deleterious to cells damaging DNA, proteins and lipids, and eventually leading to cell death

Neurobiol Aging 25(2):149157 Winterberg M, Rajendran E, Baumeister S, Bietz S, Kirk K, Lingelbach K (2012) Chemical activation of a high-affinity glutamate transporter in human erythrocytes and its implications for malaria-parasite-induced glutamate uptake