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Accordingly, diverse BTKi are currently under study for both RRMS and PPMS in ongoing clinical trials, the most advanced ones being evobrutinib and tolebrutinib (184)

Antonoff MB , Abbott AM, Rood J, Skube SJ, Mohr WJ

Graner et al showed that the isopeptidase USP2a (ubiquitin-specific protease-2a) interacts with and stabilises FASN protein in prostate cancer (Graner et al, 2004)