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The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities

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222,227 Signaling pathways linked to AD pathogenesis Neuroinflammatory signaling Several pathological factors in AD, such as A, pro-inflammatory cytokines, and oxidative stress, activate microglia and initiate downstream signaling pathways such as MAPK, NF-B, and PI3K/Akt

Current clinical management strategies, including conservative and surgical treatments, aim primarily to alleviate symptoms rather than reverse the pathological process or promote structural regeneration of the intervertebral disc (IVD)