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Thereafter, the cells exhibit circadian cycles of gene expression for several consecutive days 11,12,13

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Over time, a substantial proportion of patients develop a progressive phase, typically 10 to 15 years after disease onset, characterized by gradual accumulation of disability and ongoing neurodegeneration that becomes less directly associated with the acute inflammatory activity [104]

iNOS is essential to maintain a protective Th1/Th2 type of immune response via balanced production of proinflammatory and anti-inflammatory cytokine