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Abbreviations MSM: methyl sulphonyl methane Vit C: vitamin C GPx: glutathione peroxidise GST: glutathione transferase GR: glutathione reductase HO: heme oxygenase ROS: reactive oxygen species RNS: reactive nitrogen species NO: nitric oxide CO: carbon monoxide GSH: glutathione

A diverse bacterial community is capable of producing a broad spectrum of functional metabolites that exert systemic and metabolic effects on the host, thereby shaping what is recognized as the gut microbiome (8, 9)

Yan L, Wei JA, Yang F, Wang M, Wang S, Cheng T, Liu X, Jia Y et al (2022) Physical exercise prevented stress-induced anxiety via improving brain RNA methylation

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Moreover, it can endorse apoptosis by encouraging ROS production mediated through mitochondrial dysfunction, ER stress, and ER stress-mediated protein activation, including phosphorylation of eukaryotic initiation factor 2 (eIF2), protein kinase RNA-like ER kinase (PERK), CHOP, activating transcription factor 4 (ATF4), and cleaved-caspase 12, thereby inducing apoptosis