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Cancer Biol Med 13(1):120135 Zhao H, Ming T, Tang S, Ren S, Yang H, Liu M et al (2022) Wnt signaling in colorectal cancer: pathogenic role and therapeutic target

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The most notable clinical finding of this case is the dramatic and rapid therapeutic response with apremilast, which is faster than the efficacy reported in existing literature ( Unlike cyclosporine and methotrexate, apremilast does not cause significant immunosuppression or end-organ toxicity

But it is unprecedented for a drug to be put on the pathway to widespread adoption in this manner instead of having to go through the more arduous and evidence-based FDA drug approval process, experts say

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