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J Am Coll Cardiol 49(7):753762 Parissis JT et al (2008) Effects of darbepoetin alpha on right and left ventricular systolic and diastolic function in anemic patients with chronic heart failure secondary to ischemic or idiopathic dilated cardiomyopathy

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Less commonly, polymorphisms in the MC1R gene (common in individuals with red hair and Fitzpatrick type I skin) reduce receptor responsiveness to exogenous agonists, requiring higher doses or longer loading phases to achieve visible results

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