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Because the molecule is delicate and subject to chemical and physical degradation (peptide bond hydrolysis, oxidation, aggregation, microbial contamination), how it is stored and how long it remains effective (its shelf life) become critical for anyone handling it

Polycythemia is the opposite condition an abnormal increase in the total red blood cell mass, leading to elevated hematocrit and blood viscosity

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When children in the study got leucovorin, folate levels in their brains went up and, in some, their symptoms appeared to decrease

A physician reviewing these before starting gives you a reference point and determines whether intervention is warranted