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NADPH production is essential for the microbicidal cytosolic NADPH oxidase (NOX) system, required for netosis and for production of antimicrobial molecules (55, 56)

Based on this emerging evidence, the AASM recommended dipyridamole as an option for RLS patients who have not responded to first-line gabapentinoids (Winkelman 2025)

However, ovarian cryopreservation followed by transplantation still remains as an experimental procedure, in general, as there are numerous technical, safety and ethical issues that should be resolved and improved