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Nalapareddy et al., 2017

Diabetic cardiomyopathy (DCM) Evidence has shown that ferroptosis is crucial for DCM pathogenesis [48]

10.1016/j.tibs.2014.06.005 2

Endogenous ROS Production The main endogenous sites of cellular redox-reactive species generation-including ROS and reactive nitrogen species (RNS) comprise mitochondrial electron transport chain (ETC), endoplasmic reticulum (ER), peroxisomes, membrane-bound NADPH oxidase (NOX) isoforms 15, dual oxidases (Duox) 1 and 2 complexes, and nitric oxide synthases isoforms 15 (NOS13)

In vivo hepatic and systemic hemodynamics, and molecular markers of liver injury, fibrosis, inflammation, oxidative stress, cell death, hepatic stellate cells (HSC) activation and liver sinusoidal endothelial cells (LSEC) de-differentiation were determined