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(11) Cell wall: Like most pathogenic fungi, the cell wall of Coccidioides immitis is rich in chitin and chitin metabolism is a reasonable target for the design of antifungal agents

Next, we extended the isotopologue similarity calculation to all 13 C-labeled metabolites in RPs and non-RPs (see Isotopologue similarity between reaction-paired and non-reaction paired metabolites section in Methods )

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Third, by incorporating biomimetic coatings (such as cell membrane camouflage), targeting ligands (e.g., folic acid), and stimuli-responsive shells (like GSH- or H 2 O 2 -sensitive MnO 2 layers), COF nanoparticles gain exceptional control over their biological fate ( Figure 3 )

Therefore, it's best to get tested before starting any high-dose regimen