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From these data, sigmoidal dose-response viability curves and EC50 values are computed using Prism 5.0 (GraphPad)

It is a tripeptidemeaning its made up of three essential amino acids: Cysteine: The key player, as it provides the sulfur atom crucial for its antioxidant activity

The excess oxidative stress caused by dysfunction of SOD1 or SOD3 can also react with nitric oxide (NO) to form RNS, which in turn oxidize endothelial nitric oxide synthase (eNOS) and uncouple functional eNOS dimers

Thiffault et al., 2000) and cells (Hartley et al., 1994

Tripeptide IRW upregulates NAMPT protein levels in cells and obese C57BL/6J mice