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131 Luo et al 132 experimentally confirmed that CHR enhances spatial memory in AD rats, reduces hippocampal neuronal damage, increases the survival rate of PC12 cells induced by A 2 5 3 5 , significantly elevates GPX4 activity, GPX activity, and GSH levels in AD model rats and A-injured PC12 cells, lowers ROS and lipid peroxide (LPO) levels, improves mitochondrial pathological damage, and protects neuronal ultrastructure