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In mammalian brain development, neural circuits go through an initial rapid increase in the number of synapses followed by a gradual decrease by selective elimination via microglia-mediated pruning (Paolicelli et al., 2011)

Or you might conclude that a particular medication does not work for you, when in reality the medication was fine but the degraded vial was not delivering the full dose

The primary adaptation of bone after SCI is demineralization, which in turn increases fragility, especially at the femur and tibia in spongy bone areas of epiphyses, increasing the risk of fractures [171]

Authors: We found that oral vitamin B 12 replacement at 1000 g daily was adequate to replace vitamin B 12 levels in patients with pernicious anemia

You'll find anecdotes, forum debates, and conflicting reports that can make a straightforward research parameter feel like a formidable puzzle