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Supplementary material The Supplementary Material for this article can be found online at: References 1 AssimonM

17,21 Hence, KDS12025 is the first-in-class drug candidate that enhances the H 2 O 2 -decomposing pseudoperoxidase activity of Hb without directly scavenging H 2 O 2 , suggesting a new therapeutic approach

This is because PCA can increase glutamate levels in the brain, which can cause overstimulation and lead to headaches

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There has been some commentary on a 'reverse reaction' in which tetrahydrobiopterin (BH4) is produced when 5-methyltetrahydrofolate is converted back into methylenetetrahydrofolate