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Targeting PTDSS1 leads to GSH depletion and mitochondrial dysfunction PS catalyzed by PTDSS1 is crucial for maintaining mitochondrial functional stability and cellular structural homeostasis [16, 28]

Autofluorescence imaging of the fundus showed areas of strong autofluorescence in fundus images of aged VEGFA hyper mice, a feature associated with autofluorescent subRPE deposits as observed in AMD (Fig 11B)

The occurrence of ferroptosis is often accompanied by the dysregulation of the intracellular antioxidant system, particularly the loss of function of GPX4, which significantly reduces the cells ability to defend against lipid peroxidation ( Figure 1 )

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