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Description

All authors approved the final version of the manuscript

Mild side effects like temporary discomfort at the IV site, headache, or nausea can occur

Incorporating in vivo pharmacokinetic data or clinical evidence would enhance scientific rigor

Driving and inhibiting ferroptotic mechanisms Ferroptosis, a type of non-apoptotic cell death, is characterized by three main processes that affect the sensitivity of cells to ferroptosis: (1) an increase in the content of free iron that generates ROS through the Fenton reaction, (2) a depletion of the antioxidant glutathione (GSH) and a loss of glutathione peroxidase 4 (GPX4) activity, and (3) an accumulation of lipid peroxidation products and a disruption of cell membranes [12]