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Getting adequate sleep was shown in a study of Japanese adults that found that sleep deprivation may increase the formation of AGEs.[ref] Men with sleep apnea have higher circulating levels of AGEs and insulin resistance.[ref] Plus, sleep apnea also increases RAGE.[ref] Focusing on a regular sleep schedule, fixing sleep apnea if you have it, and prioritizing a strong circadian rhythm may be as important as diet when it comes to AGEs and RAGEs

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A study by Ilic et al

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If patients dont see any motion after six months, being seen and discussing different options may result in great benefit in the long run. Other UTSW researchers who contributed to this study were Ahneesh Mohanty, Justin Perez, Austin Hembd, and Nikhitha Thrikutam