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In Medical Toxicology

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While the inhibition of MAO-A in the brain is necessary for an antidepressant effect, inhibition of both MAO-A and MAO-B provides a greater increase in serotonin, norepinephrine, and dopamine than inhibition of either MAOI isomer alone (Figure 1A and B).27,29 Theoretically, inhibition of both MAO-A and MAO-B can lead to greater increases of each neurotransmitter compared with inhibition of either isoenzyme alone

Calycosin and GA synergistically induced the expression of Leukotriene B4 12-Hydroxydehydrogenase (LTB4DH) in HepG2 cells and human neutrophils, which can be used to limit neutrophil infiltration and subsequent myocardial injury