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Thus, the PPPgenerated NADPH rescues xCT-overexpressing cancer cells (xCT high cancer cells) from ferroptosis, demonstrating that xCT high cancer cells become highly dependent on the glucose-PPP pathway (i.e., NADPH addiction) to inhibit ferroptosis [Figure 1A]

Gln metabolism directly or indirectly influences epigenetic processes, such as DNA methylation and histone modification, through mechanisms of substrate supply and cofactor regulation

Maintenance After the initial boost, many people transition to a maintenance schedule

However, these strategies are characterized by different levels of technological maturity and practical applicability

(2024) 5:e606