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In genetically susceptible individuals with HLA-DR haplotypes impairing antigen presentation, these exposures provoke a failure to regulate the innate immune response, leading to a chronic, self-sustaining cascade of inflammation

1 A detailed review of COPD guidelines and the pharmacologic management of COPD symptoms was previously summarized and may also be found within the 2024 GOLD guidelines

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Pemphigus foliaceus associated with absence of intercellular antigens in lower layers of epidermis

Newton and J.J