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Previous studies by our group and others have shown that non-degradative ubiquitination modifications may alter protein activity, subcellular localization, and protein-protein interactions, etc, playing a key role in a variety of cellular processes, including cell signaling, DNA damage repair, cell cycle regulation, and immune responses [46, 47]

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ACG recommendations are graded Strong when benefits outweigh risks

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Current knowledge suggests that new therapies aiming at restoring the energy balance in the heart should be used on top of current therapies to better treat HF patients and improve quality of life and possibly survival